Wildlife management agencies in regions where chronic wasting disease (CWD) is prevalent have adopted costly management practices to mitigate the spread of this fatal and highly transmissible disease. Non-market valuation represents a critical tool for managers attempting to address these costs, but the mode and methods of contingent valuation (CV) questions can impact valuations due to biases inherent to self-reporting economic decisions. We administered online (n = 1430) and phone (n = 602) surveys in North Carolina and South Carolina to assess what hunters with licenses to hunt white-tailed deer (Odocoileus virginianus) were willing to pay for CWD testing and carcass disposal across survey modes and CV methods. Among the online survey respondents, 34.1% (n = 488) were willing to pay for testing and 43.4% (n = 620) were willing to pay for disposal. From our phone sample, 48.6% (n = 293) were willing to pay for testing and 50.7% (n = 306) for disposal. Survey mode affected mean willingness to pay (WTP) in open-ended questions, with lower estimates from the online survey (M = US$15.96 for testing; $14.74 for disposal) than for the phone survey (M = $22.90 for testing; $22.80 for disposal). Different CV methods, however, yielded minor differences in WTP estimates reported on our phone survey (dichotomous choice: M = $24.80 for testing; $24.50 for disposal). Greater WTP estimates in phone surveys, relative to online, may be explained by interviewer effects. The fact that cost-efficient, open-ended WTP methods produced average WTP values nearly identical to those generated by the more complex and costly dichotomous choice methods is encouraging, but greater variance for open-ended methods remains an important limitation. Our research provides some justification for using relatively easy open-ended CV methods of assessing WTP for wildlife disease management and underscores the need to account for survey mode when collecting and interpreting data about WTP.