Radio telemetry and mark-recapture techniques were used to monitor linear ranges of large (TL > 510 mm) flathead catfish {Pylodictis olivaris) in the Big Black River and the Tallahatchie River, Mississippi. Linear ranges of transmitter-tagged fish averaged 0.75 km (SE = 0.09 km, N = 6) in the Big Black River and 1.04 km (SE = 0.13 km, N = 8) in the Tallahatchie River. In the Big Black River, 116 adult flathead catfish were tagged with Floy T-Bar anchor tags. There were 6 recaptures from the Big Black River with all recaptures occurring <2 km from release sites. In the Tallahatchie River, 103 adult flathead catfish were tagged with Floy T-Bar anchor tags. There were 5 recaptures from the Tallahatchie River with all but 1 recapture occurring <1 km from release sites. A stream reach-specific approach is suggested for management of large flathead catfish. For the Big Black River and Tallahatchie River, a resolution of 2 km is recommended for these purposes.