Tissues from 61 mink (Mustela vison) harvested in two areas in South Carolina during the 1987-88 season were screened for pesticide, PCB, and heavy metal residues. Low levels of DDT and DDE were detected. Although 90% of samples contained measurable levels of DDE, the low concentrations found in all but I animal should not present any problems to these mink populations. Many (43%) samples contained PCBs, and all samples had detectible heavy metal residues. Levels did not approach those published for mink that suffered mortality in laboratory studies; however, sublethal effects on mink reproduction need to be considered.